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KMID : 1200020170410050349
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Diabetes & Metabolism Journal
2017 Volume.41 No. 5 p.349 ~ p.356
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Monotherapy in Patients with Type 2 Diabetes Mellitus
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Rhee Sang-Youl
Kim Hyun-Jin
Ko Seung-Hyun
Hur Kyu-Yeon
Kim Nan-Hee
Moon Min-Kyong
Park Seok-O
Lee Byung-Wan
Choi Kyung-Mook
Kim Jin-Hwa
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Abstract
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In order to improve the quality of life and to prevent chronic complications related to diabetes mellitus, intensive lifestyle modification and proper medication are needed from the early stage of diagnosis of type 2 diabetes mellitus (T2DM). When using the first medication for diabetic patients, the appropriate treatment should be selected considering the clinical characteristics of the patient, efficacy of the drug, side effects, and cost. In general, the use of metformin as the first treatment for oral hypoglycemic monotherapy is recommended because of its excellent blood glucose-lowering effect, relatively low side effects, long-term proven safety, low risk of hypoglycemia, and low weight gain. If metformin is difficult to use as a first-line treatment, other appropriate medications should be selected in view of the clinical situation. If the goal of achieving glycemic control is not achieved by monotherapy, a combination therapy with different mechanisms of action should be initiated promptly.
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KEYWORD
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Diabetes mellitus, type 2, Hypoglycemic agents, Metformin, Practice guideline
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